The Laszlo Letter

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2012 - A Survival Guide

The following first appeared on the Pharmaceutical Users Software Exchange (PhUSE) Facebook page. 

Happy New Year to you.  I am saying ‘to you’ deliberately since I’d like this post to be read as if we were good friends having a chat in a cafe over a cup of coffee. I realize though that by the time you finish reading this you may not want to be my friend. Let’s see what happens.

First, I want you to know that I consider you a professional; someone really good at what you do. So, I’m not going to dwell on that except to say that you may need to be a bit more open to learning new things so you can survive the hard times ahead. More about that later...

As I write this post, Astra Zeneca has announced another round of layoffs, this time affecting over 1,200 employees. Most of these will be in Sales. Don’t let that make you complacent. While the industry has finally figured out that you can’t have nearly as many reps as there are physicians, they may have also determined that all other professions are fair game too. That means you!

So, how will you survive and thrive? Good question. Let’s come back to that later as well...

I’d like to share with you a cautionary tale. A few years ago, I was helping Elan implement a new clinical data management system. As always, my team had the chance to work with some really bright programmers and statisticians. This did not mean that all of them were enthused about the solution that was selected. You could say that we had the typical bell curve; a few people who were really enthusiastic, a large number who would go along without complaint, and a few others who were silently or vocally opposed.

Anyway, no matter what you believed, the marching orders were clear and you were expected to help implement the new system and the processes that went with it. We had lots of planning meetings and everyone had important tasks that had to be completed on schedule. And did I mention that everyone still had to do their regular jobs! Then, one bright sunny morning we came to the office only to find out that six of the team members were let go the previous day. Not only that, but the entire project was scrapped. We packed our bags and went home.

On the plane back to New York, I had the chance to reflect on what happened. First, I felt bad for all of those who were let go. I then made myself feel a bit better by rationalizing. Specifically, I thought that some of these people probably hated what they were doing or loathed the company they worked for but were afraid to make a move. Now they had no choice and would most likely land on their feet.

Then I thought about the naysayers who were also fired, those who had to be dragged kicking and screaming to adopt the new system we were trying to implement. How ironic, I thought. Whatever job they got next, they would need to go along with whatever system and processes are already in place. They would need to work with whatever cards they were dealt.

So, there are a few important lessons wrapped up in this cautionary tale. The most important one is that you have to keep things in perspective. It’s important to have principles and convictions but you also need to be critical of yourself and not just of others. For example, is it possible that you may be wrong about the new system? Is the real reason for objecting your fear of the unknown or having to learn something new? Would you be protesting as loudly if you knew that you will be out the door the next morning? And finally, why can’t you think of the new system and processes as if you were showing up at a new job with a different company the next day?

Oh, this reminds me. Did I tell you about the conversation I had the other day with my friend Audi. I know, I know, it sounds like the car but it’s a real Arabic name. She came to the United States from Syria and is still struggling to understand our ways. Anyway, we somehow got into a conversation about God. She wanted to know if I believed in God. I told her that it’s not something I think about. But she would not let it go at that saying “Just think about the universe and all the things that exist? It could not just have come from nothing?”  So I gave it another try. I said “Audi, it’s pretty simple for me. We humans are pretty limited. We have trouble thinking outside of ourselves. And besides, it’s arrogant for us to even think that we could know who God is? See, I just humanized God without even thinking!  Is God a ‘who’?  It’s only because we have a big brain and self awareness that allows us to even think about God. And what do we accomplish anyway? It makes no difference whether I believe in God or not. It won’t change anything.” I don’t think I convinced her.

Then I smiled and said: “Audi, did I ever tell you the joke about husbands and wives? The one about big and small decisions?  It’s pretty simple. Wives let their husbands make the big decisions like ‘how we can solve the deficit problem or world hunger’.  Wives make the small decisions like ‘where we’re going to live, where our children go to school and what we’ll do for our summer vacation.’” She laughed at that.

So we have another important lesson. Try not to think or worry about things over which you have no control. Focus on things that you can influence or control. Maybe that is how we’ll all make it through 2012 unscathed!

I know, it’s easier said than done. You come to work every day and do what is expected.  Come to think of it, you’ve been pretty lucky in Biostatistics. All of your customers think of you as a black box. They send in the raw materials and you give them a finished product. They have no idea how you do it and I don’t even think they care. It’s nice that you have control.

Or is it? The company as a whole is in big trouble? Do you know why? It’s probably pretty complex. Maybe you need to understand that better. I guess I’m suggesting that as an employee you have a responsibility not only to do your job but to think about the success of your fellow employees and that of the company as a whole. You know, if you don’t care about them, why should they care about you?

For example, you know that the cost of R&D is astronomical and always going up. Yet, the chance of success with any candidate is going down. So, what can you do to get that R&D buck to go further? Just think about it?

OK, I’ll give you an example. SAS is pretty useful to your job but it’s also very expensive. On the other hand, there is R which may be just as good and perhaps even better at some things. And did I mention that it costs a fraction of the big gorilla?

I know, I know, you have a ton of people who are SAS experts (including you). But if you know that you can save your company a lot of money by switching, why aren’t you doing it and doing it faster? Aren’t you smart enough to make it successful and yourself more valuable in the marketplace? Would you rather risk losing your job so that management can hire someone who knows R better than you? Which is better: Having your friend in the next cubicle keep his job or have some employee at SAS Institute eat as many M&M’s as they want? It’s partly up to you, you know.

Sorry, I got carried away there. Sometimes I get emotional about this stuff. But you have to understand. It’s a dog eat dog world out there and you can’t just stand by as an observer anymore. You have to be active to save yourself and stay ahead of the competition.

You know what the enemy is? Time! The clock is ticking for this entire industry and we are still doing our jobs in slow motion. We used to call this the “Fat and Happy Syndrome.” I have a variation on this that I shamelessly call Laszlo’s Law. This states that change in the biopharma industry takes the same amount of time as drug discovery and development. In other words, we’ve come to accept that it takes 8-12 years to get a product to market and thus, it must take equally long to get anything else done too. Read it and weep!

Since I’m an IT guy, I will give you two examples of this.

Q: How long did it take for Documentum to be accepted and widely used for regulated document management?

A: About 8-12 years

Q: How long did it take for EDC to be used more widely than hard copy CRF’s?

A: About 8-12 years

And yes, you can do something about this. Just look around you, observe and ask questions. Why, for example, is it taking so long to adopt R? Why do we have 3-5 year transition plans from one system to another? Why can’t I get my hands on the clinical data from study X in 3 minutes rather than 3 months? Why can’t I have my EDC system be reconciled with my AE system in real time? Why do I have to re-run 20 programs to modify single footer? Why isn’t it possible to (insert your own question here)?

If you can ask these questions and derive solutions from them, you have all the ammunition you need to take your case to management. No topic/issue should be off limits. If you don’t do something about it, who will? Rest assured, someone will and you may not like the outcome. Proactive beats reactive anytime.

Speaking of Management, you may not know this but you also have the responsibility to keep them honest.

Want to save more money and perhaps some jobs? Look into your company’s travel policies. Is it OK for employees to spend $80 for dinner when their colleagues are being laid off? Can you stand it sitting in coach flying from New York to Frankfurt at $1,000 rather than $3,500 in business class? Are you taking advantage just because you can? How about some self direction? Be proactive and fly coach even if the policy says otherwise. Then let everyone know that you did it and why. Better yet, ask Management to review and revise the whole travel program. Ask them to build in some incentives (Read $$$ and €€€) to get T&E costs as low as possible.

OK, you don’t think that’s important enough? Well, how about this? Do you know if your company and its employees are following corporate governance policies? Did you know that those are even posted on the company web site? How about the ethical guidelines?

Did you hear about that giant company that just paid close to $1 billion to settle an illegal marketing scheme? No admittance of guilt of course. Was it your company? Were you outraged? Here you are doing your job and know that your fellow colleagues are also doing their best. How is it possible that a few misfits are making you into a villain in the eyes of the public? Aren’t you working in healthcare because it actually makes life better for mankind?

Oops. There I go again. But yes, stuff like this happens because someone was only interested in the bottom line. A game, if you will, where you gamble that you’ll make inordinately more than what it will cost you to settle. It’s not only money this time. The reputation of your company and the industry is at stake.

So, yes, it’s up to you to keep your own company honest. To protect it from itself.  That means that you need to understand how it’s governed and evaluate for yourself whether its policies actually work. If not, you need to bring up the issue with the powers that be. Perhaps not alone but with your fellow employees.

 By the way, did you hear that some of the Novartis employees and a local union actually staged a public protest about the layoffs at their Nyon facility? That’s in Switzerland. Amazing!

Happy New Year

George

Friday, 06 January 2012 in 05 Industry Controversy, 70 Ethics and Compliance, 71 Public Relations, 73 Human Resources, 90 Diversions, 94 Random Thoughts | Permalink | Comments (1) | TrackBack (0)

Technorati Tags: Astra Zeneca, biostatistics, clinical trials, data management, Elan, ethics, human resources, industry practices, jobs, Laszlo Letter, layoffs, pharmaceuticals, reduction in force, statistical programming, Survival guide

Civil War 2.0 - The 'Haves' vs. the 'Have-nots'

Until now, I have refrained from stating my political and societal views on this site. There is, however, a disturbing trend gaining steam in the United States (and to a lesser extent in the rest of the developed world) that all of us should be aware of and (through careful consideration) guide our actions as citizens of this great country.

The trend I am speaking of is the expanding chasm between the economic upper class and those in the middle or lower classes. I was reminded of this again through an article by Joseph Stiglitz in the May issue of Vanity Fair. The title of the article was "Of the 1%, by the 1%, for the 1%" and was neatly buried on page 126. Even the editors of Vanity Fair felt that Rob Lowe, Golman Sachs and the Royal Wedding deserved more attention.

The title of the article is both catchy and correct. When 1% of the population is pulling in 1/4 of total income every year and has 40% of the total wealth of the country, you know that something is out of balance. You could argue that this is OK as long as the rest of the populace is also benefiting from an upward income and wealth trend. Unfortunately just the opposite is the case and has been so for years.

Although most of us working in the biopharmaceutical industry have been quite fortunate to make a comfortable middle class living, the trend is not headed in the right direction for us either. Witness the latest headline on the on-line CBS Interactive Business Network (BNET): "Teva Merger: Cephalon CEO Gets $5M for 3 Months’ Work; Staff Gets Layoffs."

In the latter article, we learn exactly what the headline says (i.e. CEO walks away with $5 million) and what is also implied (i.e. that layoffs are expected to save $500 million within 3 years). Although Teva is a first rate company and certainly better run than Cephalon, the layoffs from the merger are inevitable. Personally, I am not upset about the $5 million payoff even if Cephalon's President is getting it after only 4 months on the job. After all, we all would love to be in his position. Unfortunately, those getting laid off are in for a great deal of anxiety given current market conditions.

Disclaimer: I have personally done work for Teva in the past and completed a small engagement for them just this year.

 As for the Stiglitz article, what cought my eye was the following penultimate paragraph:

"Alexis de Tocqueville once described what he saw as a chief part of the peculiar genius of American society—something he called “self-interest properly understood.” The last two words were the key. Everyone possesses self-interest in a narrow sense: I want what’s good for me right now! Self-interest “properly understood” is different. It means appreciating that paying attention to everyone else’s self-interest—in other words, the common welfare—is in fact a precondition for one’s own ultimate well-being. Tocqueville was not suggesting that there was anything noble or idealistic about this outlook—in fact, he was suggesting the opposite. It was a mark of American pragmatism. Those canny Americans understood a basic fact: looking out for the other guy isn’t just good for the soul—it’s good for business."

In short, it is natural as one gets richer and richer to have less and less empathy for your fellow man. The rationalisation goes something like this: "I worked hard to become successful. If the guy next door could not do the same, that's his problem." It is thus up to our government to recognize that hubris and arrogance must be held in check using legislative means and via social programs that adequately balance capitalism with the social good.

Given the current political climate I fear that not much progress will be made on this front in the coming years. And certainly not if Obama is defeated in 2012. So take heed, just as we now clearly know that our first Civil War was an economic vs. human rights issue pitting north versus south, if the gap between the rich and not-so rich widens further, our next Civil War will be a lot messier and will pit the 'haves' vs. the 'have-nots.'

Friday, 06 May 2011 in 05 Industry Controversy, 70 Ethics and Compliance, 73 Human Resources, 74 Legal and Government Relations, 90 Diversions, 94 Random Thoughts | Permalink | Comments (0) | TrackBack (0)

Technorati Tags: balance of power, capitalism, Cephalon, civil war, empathy, hubris, Inequality, Laszlo Letter, merger, personal income, poverty, social good, social welfare, society, Teva, Toqueville, wealth

Three Developments to Watch

Welcome to my leap-year post!

Although our industry is notoriously slow to adopt new technologies, it is also true that eventually we wake up and attempt to catch up with the rest of the world. With this in mind, here are three developments worth watching:

Google dives into content management and collaboration

Read this to get a feel for the direction Google is taking to take on Microsoft SharePoint on the enterprise collaboration and content management front. Yes, it's a "dumbed down" attempt at the moment but not one to be ignored. While you're at it, check out a currently more serious competitive product from Alfresco.

Adobe Air to unite the Internet with PC applications

Here is a novel thought: Get access to your PC-based applications via the Internet no matter where you may be and even if you don't have your PC with you. Adobe Air plans to enable that but will require an army of developers to make it happen. Read this article to learn more and perhaps check out some already existing applications that use Air. You'll find links to them in the article. As with everything else in life, there is competition. So, don't forget to check out what Microsoft, OpenLaszlo (no relation) and XCerion are doing on this front.

EMC sticks toe in cloud computing waters

Paraphrasing its Wikipedia description, "cloud computing is a massive network of computer servers interconnected as if in a grid running in parallel to maximize computing power per server." While this concept and practice has been around for quite a while under the name of "grid computing" it has taken on new meaning due to the huge investment put behind it by Google to power its own worldwide infrastructure. Since cloud computing has tremendous implications for data storage, it is easy to see why EMC has now purchased Pi Corporation to seed its new Cloud Infrastructure and Services Division. So, check out what's going on here starting with this article. And yes, while EMC also owns the Documentum brand, don't expect this new development to have much impact there in the near future. The big bucks will come from elsewhere. In our own industry, think about "omics" as the most likely place where cloud computing can have a big role.

Friday, 29 February 2008 in 94 Random Thoughts | Permalink | Comments (0) | TrackBack (0)

Technorati Tags: Adobe, cloud computing, collaboration, content management, EMC, Google, grid computing, Laszlo Letter, Microsoft

IBM buys into Complex Event Processing (CEP)

FishI have been following the progress of a small company called AptSoft for about two years. AptSoft markets a solution for Complex Event Processing (CEP), a niche capability that is a close cousin of Business Process Management (BPM).

As I have reported here not long ago, I have been struck by the great emphasis our industry has put on process reengineering while almost ignoring the important role that BPM tools could play to make such reengineering easier and more effective. So, I have been reluctant to add CEP into the mix under the assumption that our industry was just not ready for it.

Now comes the important news that IBM has purchased AptSoft and will make it part of its WebSphere business. This move by IBM will give greater legitimacy to CEP even if it only becomes a part of a larger set of middleware and SOA offerings.

The move also means that the biopharma industry should take a closer look at the way that CEP could be used througout the business. But just what are these application areas?

Well, I don't have a nice compact list to share with you. Suffice it to say that CEP can help in circumstances where the potential consequence of a sequence of events are not known. In other words, you can use BPM when you know for sure what effects a certain action can have. You can use CEP if you don't know any or all of the effects that may transpire. Donald Rumsfeld would call these the unknown unknowns. And, as an added bonus, CEP would let you figure out how to handle these unknowns as they happen.

OK, I'll give you one example: Supply chain management in case of a pandemic of unknown size and location.

Friday, 25 January 2008 in 42 Workflow & Process Management, 94 Random Thoughts, 99 Vendors | Permalink | Comments (0) | TrackBack (0)

Technorati Tags: AptSoft, BMP, CEP, complex event processing, IBM, Laszlo Letter, pandemic

Random Thoughts: Women in Leadership Positions

and why we need more of them in this industry.

Womentalk I have always been amazed that when my wife and I meet another married couple, she is able to find out everything about their families from the wife in roughly 20 minutes. I, on the other hand, may become the best friend of the husband and fail to know, perhaps even after two years, that he has two brothers and a sister. And therein lies a great difference between men and women. Women are simply better at communicating.

So, why does this lead me to conclude that we need more women in leadership positions in our industry? There are probably many reasons but only one that led me to writing this post. It's about an incident fairly recently wherein a very large pharma company forbade one of their employees from giving me a copy of his presentation at a very public meeting and also (politely) asked me not to write anything about the talk.

While I was not surprised by this incident, I still managed to get pretty upset about it. And that's when I realized that this was male testosterone (theirs, not mine) at work. Inexplicable, irrational, illogical and infuriating. Yes, I know I'm getting emotional about this but only because such behavior has consequences. This crazy focus on secrecy (read: lack of transparency) inhibits progress. We need to learn from each others triumphs and failures so the entire industry can grow.

This is why we need more women in leadership roles. They know much better how to communicate and collaborate. Wrapped in all that is a greater degree of openness that values discussing the bad as well as the good.

Now please excuse me, I have to go work a bit on my feminine side.

Saturday, 17 November 2007 in 94 Random Thoughts | Permalink | Comments (0) | TrackBack (0)

Technorati Tags: collaboration, communication, Laszlo Letter, men, secrecy, women

Random Thoughts: Sub-prime Leadership

The following is the first entry under this new category of Random Thoughts. These are meant to be short and sweet and hopefully trigger some reaction in your own brain.

I just learned that E. Stanley O’Neal, Chairman and CEO of Merrill Lynch is leaving that firm following the need to write down $8.4 billion related to the real estate subprime mess. Now, $8.4 billion is a lot of money and someone does need to take responsibility for allowing a debacle of that scale to develop. When the loss is that great, it's appropriate that the top guy turns into the fall guy.

So let's reflect on this but with the perspective turned toward our own Biopharma industry. The nearest example I can think of is the ouster of Peter Dolan as CEO of BMS back in September 2006. Mind you, Mr. Dolan was not exactly volunteering to take responsibilty for his management of the company. Perhaps we would all be better served if some other members of top management recognized their own weaknesses and/or bad leadership and volunteered for the exit rather than being shown the door.

Monday, 29 October 2007 in 94 Random Thoughts | Permalink | Comments (0) | TrackBack (0)

Technorati Tags: BMS, E. Stanley O’Neal, Laszlo Letter, leadership, Merrill Lynch, Peter Dolan

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