The Laszlo Letter

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2012 - A Survival Guide

The following first appeared on the Pharmaceutical Users Software Exchange (PhUSE) Facebook page. 

Happy New Year to you.  I am saying ‘to you’ deliberately since I’d like this post to be read as if we were good friends having a chat in a cafe over a cup of coffee. I realize though that by the time you finish reading this you may not want to be my friend. Let’s see what happens.

First, I want you to know that I consider you a professional; someone really good at what you do. So, I’m not going to dwell on that except to say that you may need to be a bit more open to learning new things so you can survive the hard times ahead. More about that later...

As I write this post, Astra Zeneca has announced another round of layoffs, this time affecting over 1,200 employees. Most of these will be in Sales. Don’t let that make you complacent. While the industry has finally figured out that you can’t have nearly as many reps as there are physicians, they may have also determined that all other professions are fair game too. That means you!

So, how will you survive and thrive? Good question. Let’s come back to that later as well...

I’d like to share with you a cautionary tale. A few years ago, I was helping Elan implement a new clinical data management system. As always, my team had the chance to work with some really bright programmers and statisticians. This did not mean that all of them were enthused about the solution that was selected. You could say that we had the typical bell curve; a few people who were really enthusiastic, a large number who would go along without complaint, and a few others who were silently or vocally opposed.

Anyway, no matter what you believed, the marching orders were clear and you were expected to help implement the new system and the processes that went with it. We had lots of planning meetings and everyone had important tasks that had to be completed on schedule. And did I mention that everyone still had to do their regular jobs! Then, one bright sunny morning we came to the office only to find out that six of the team members were let go the previous day. Not only that, but the entire project was scrapped. We packed our bags and went home.

On the plane back to New York, I had the chance to reflect on what happened. First, I felt bad for all of those who were let go. I then made myself feel a bit better by rationalizing. Specifically, I thought that some of these people probably hated what they were doing or loathed the company they worked for but were afraid to make a move. Now they had no choice and would most likely land on their feet.

Then I thought about the naysayers who were also fired, those who had to be dragged kicking and screaming to adopt the new system we were trying to implement. How ironic, I thought. Whatever job they got next, they would need to go along with whatever system and processes are already in place. They would need to work with whatever cards they were dealt.

So, there are a few important lessons wrapped up in this cautionary tale. The most important one is that you have to keep things in perspective. It’s important to have principles and convictions but you also need to be critical of yourself and not just of others. For example, is it possible that you may be wrong about the new system? Is the real reason for objecting your fear of the unknown or having to learn something new? Would you be protesting as loudly if you knew that you will be out the door the next morning? And finally, why can’t you think of the new system and processes as if you were showing up at a new job with a different company the next day?

Oh, this reminds me. Did I tell you about the conversation I had the other day with my friend Audi. I know, I know, it sounds like the car but it’s a real Arabic name. She came to the United States from Syria and is still struggling to understand our ways. Anyway, we somehow got into a conversation about God. She wanted to know if I believed in God. I told her that it’s not something I think about. But she would not let it go at that saying “Just think about the universe and all the things that exist? It could not just have come from nothing?”  So I gave it another try. I said “Audi, it’s pretty simple for me. We humans are pretty limited. We have trouble thinking outside of ourselves. And besides, it’s arrogant for us to even think that we could know who God is? See, I just humanized God without even thinking!  Is God a ‘who’?  It’s only because we have a big brain and self awareness that allows us to even think about God. And what do we accomplish anyway? It makes no difference whether I believe in God or not. It won’t change anything.” I don’t think I convinced her.

Then I smiled and said: “Audi, did I ever tell you the joke about husbands and wives? The one about big and small decisions?  It’s pretty simple. Wives let their husbands make the big decisions like ‘how we can solve the deficit problem or world hunger’.  Wives make the small decisions like ‘where we’re going to live, where our children go to school and what we’ll do for our summer vacation.’” She laughed at that.

So we have another important lesson. Try not to think or worry about things over which you have no control. Focus on things that you can influence or control. Maybe that is how we’ll all make it through 2012 unscathed!

I know, it’s easier said than done. You come to work every day and do what is expected.  Come to think of it, you’ve been pretty lucky in Biostatistics. All of your customers think of you as a black box. They send in the raw materials and you give them a finished product. They have no idea how you do it and I don’t even think they care. It’s nice that you have control.

Or is it? The company as a whole is in big trouble? Do you know why? It’s probably pretty complex. Maybe you need to understand that better. I guess I’m suggesting that as an employee you have a responsibility not only to do your job but to think about the success of your fellow employees and that of the company as a whole. You know, if you don’t care about them, why should they care about you?

For example, you know that the cost of R&D is astronomical and always going up. Yet, the chance of success with any candidate is going down. So, what can you do to get that R&D buck to go further? Just think about it?

OK, I’ll give you an example. SAS is pretty useful to your job but it’s also very expensive. On the other hand, there is R which may be just as good and perhaps even better at some things. And did I mention that it costs a fraction of the big gorilla?

I know, I know, you have a ton of people who are SAS experts (including you). But if you know that you can save your company a lot of money by switching, why aren’t you doing it and doing it faster? Aren’t you smart enough to make it successful and yourself more valuable in the marketplace? Would you rather risk losing your job so that management can hire someone who knows R better than you? Which is better: Having your friend in the next cubicle keep his job or have some employee at SAS Institute eat as many M&M’s as they want? It’s partly up to you, you know.

Sorry, I got carried away there. Sometimes I get emotional about this stuff. But you have to understand. It’s a dog eat dog world out there and you can’t just stand by as an observer anymore. You have to be active to save yourself and stay ahead of the competition.

You know what the enemy is? Time! The clock is ticking for this entire industry and we are still doing our jobs in slow motion. We used to call this the “Fat and Happy Syndrome.” I have a variation on this that I shamelessly call Laszlo’s Law. This states that change in the biopharma industry takes the same amount of time as drug discovery and development. In other words, we’ve come to accept that it takes 8-12 years to get a product to market and thus, it must take equally long to get anything else done too. Read it and weep!

Since I’m an IT guy, I will give you two examples of this.

Q: How long did it take for Documentum to be accepted and widely used for regulated document management?

A: About 8-12 years

Q: How long did it take for EDC to be used more widely than hard copy CRF’s?

A: About 8-12 years

And yes, you can do something about this. Just look around you, observe and ask questions. Why, for example, is it taking so long to adopt R? Why do we have 3-5 year transition plans from one system to another? Why can’t I get my hands on the clinical data from study X in 3 minutes rather than 3 months? Why can’t I have my EDC system be reconciled with my AE system in real time? Why do I have to re-run 20 programs to modify single footer? Why isn’t it possible to (insert your own question here)?

If you can ask these questions and derive solutions from them, you have all the ammunition you need to take your case to management. No topic/issue should be off limits. If you don’t do something about it, who will? Rest assured, someone will and you may not like the outcome. Proactive beats reactive anytime.

Speaking of Management, you may not know this but you also have the responsibility to keep them honest.

Want to save more money and perhaps some jobs? Look into your company’s travel policies. Is it OK for employees to spend $80 for dinner when their colleagues are being laid off? Can you stand it sitting in coach flying from New York to Frankfurt at $1,000 rather than $3,500 in business class? Are you taking advantage just because you can? How about some self direction? Be proactive and fly coach even if the policy says otherwise. Then let everyone know that you did it and why. Better yet, ask Management to review and revise the whole travel program. Ask them to build in some incentives (Read $$$ and €€€) to get T&E costs as low as possible.

OK, you don’t think that’s important enough? Well, how about this? Do you know if your company and its employees are following corporate governance policies? Did you know that those are even posted on the company web site? How about the ethical guidelines?

Did you hear about that giant company that just paid close to $1 billion to settle an illegal marketing scheme? No admittance of guilt of course. Was it your company? Were you outraged? Here you are doing your job and know that your fellow colleagues are also doing their best. How is it possible that a few misfits are making you into a villain in the eyes of the public? Aren’t you working in healthcare because it actually makes life better for mankind?

Oops. There I go again. But yes, stuff like this happens because someone was only interested in the bottom line. A game, if you will, where you gamble that you’ll make inordinately more than what it will cost you to settle. It’s not only money this time. The reputation of your company and the industry is at stake.

So, yes, it’s up to you to keep your own company honest. To protect it from itself.  That means that you need to understand how it’s governed and evaluate for yourself whether its policies actually work. If not, you need to bring up the issue with the powers that be. Perhaps not alone but with your fellow employees.

 By the way, did you hear that some of the Novartis employees and a local union actually staged a public protest about the layoffs at their Nyon facility? That’s in Switzerland. Amazing!

Happy New Year

George

Friday, 06 January 2012 in 05 Industry Controversy, 70 Ethics and Compliance, 71 Public Relations, 73 Human Resources, 90 Diversions, 94 Random Thoughts | Permalink | Comments (1) | TrackBack (0)

Technorati Tags: Astra Zeneca, biostatistics, clinical trials, data management, Elan, ethics, human resources, industry practices, jobs, Laszlo Letter, layoffs, pharmaceuticals, reduction in force, statistical programming, Survival guide

Reward Yourself. Make a Donation to Wikipedia

If you've connected Wikipedia at any time over the past two months, you know that they have been asking people to donate money so they can keep the site up and running. This is one of the few really useful web sites out there that don't rely at all on advertising.

So, today and tomorrow are the last two days when you can make a tax deductible contribution.

Click HERE to go to their site.

DO IT. You'll feel really good as soon as you click that payment button.

Happy New Year

George

Friday, 30 December 2011 in 90 Diversions | Permalink | Comments (0) | TrackBack (0)

Technorati Tags: donation, Laszlo Letter, wikimedia, Wikipedia

Civil War 2.0 - The 'Haves' vs. the 'Have-nots'

Until now, I have refrained from stating my political and societal views on this site. There is, however, a disturbing trend gaining steam in the United States (and to a lesser extent in the rest of the developed world) that all of us should be aware of and (through careful consideration) guide our actions as citizens of this great country.

The trend I am speaking of is the expanding chasm between the economic upper class and those in the middle or lower classes. I was reminded of this again through an article by Joseph Stiglitz in the May issue of Vanity Fair. The title of the article was "Of the 1%, by the 1%, for the 1%" and was neatly buried on page 126. Even the editors of Vanity Fair felt that Rob Lowe, Golman Sachs and the Royal Wedding deserved more attention.

The title of the article is both catchy and correct. When 1% of the population is pulling in 1/4 of total income every year and has 40% of the total wealth of the country, you know that something is out of balance. You could argue that this is OK as long as the rest of the populace is also benefiting from an upward income and wealth trend. Unfortunately just the opposite is the case and has been so for years.

Although most of us working in the biopharmaceutical industry have been quite fortunate to make a comfortable middle class living, the trend is not headed in the right direction for us either. Witness the latest headline on the on-line CBS Interactive Business Network (BNET): "Teva Merger: Cephalon CEO Gets $5M for 3 Months’ Work; Staff Gets Layoffs."

In the latter article, we learn exactly what the headline says (i.e. CEO walks away with $5 million) and what is also implied (i.e. that layoffs are expected to save $500 million within 3 years). Although Teva is a first rate company and certainly better run than Cephalon, the layoffs from the merger are inevitable. Personally, I am not upset about the $5 million payoff even if Cephalon's President is getting it after only 4 months on the job. After all, we all would love to be in his position. Unfortunately, those getting laid off are in for a great deal of anxiety given current market conditions.

Disclaimer: I have personally done work for Teva in the past and completed a small engagement for them just this year.

 As for the Stiglitz article, what cought my eye was the following penultimate paragraph:

"Alexis de Tocqueville once described what he saw as a chief part of the peculiar genius of American society—something he called “self-interest properly understood.” The last two words were the key. Everyone possesses self-interest in a narrow sense: I want what’s good for me right now! Self-interest “properly understood” is different. It means appreciating that paying attention to everyone else’s self-interest—in other words, the common welfare—is in fact a precondition for one’s own ultimate well-being. Tocqueville was not suggesting that there was anything noble or idealistic about this outlook—in fact, he was suggesting the opposite. It was a mark of American pragmatism. Those canny Americans understood a basic fact: looking out for the other guy isn’t just good for the soul—it’s good for business."

In short, it is natural as one gets richer and richer to have less and less empathy for your fellow man. The rationalisation goes something like this: "I worked hard to become successful. If the guy next door could not do the same, that's his problem." It is thus up to our government to recognize that hubris and arrogance must be held in check using legislative means and via social programs that adequately balance capitalism with the social good.

Given the current political climate I fear that not much progress will be made on this front in the coming years. And certainly not if Obama is defeated in 2012. So take heed, just as we now clearly know that our first Civil War was an economic vs. human rights issue pitting north versus south, if the gap between the rich and not-so rich widens further, our next Civil War will be a lot messier and will pit the 'haves' vs. the 'have-nots.'

Friday, 06 May 2011 in 05 Industry Controversy, 70 Ethics and Compliance, 73 Human Resources, 74 Legal and Government Relations, 90 Diversions, 94 Random Thoughts | Permalink | Comments (0) | TrackBack (0)

Technorati Tags: balance of power, capitalism, Cephalon, civil war, empathy, hubris, Inequality, Laszlo Letter, merger, personal income, poverty, social good, social welfare, society, Teva, Toqueville, wealth

Photo / Slide Animation of the Fun Kind

AnimotoMany of you have thanked me for turning you on to the Blurb digital photo publishing tool. Continuing in that vein, I want to make you aware of a web site called Animoto.

The concept and the execution is really simple. You select a set of digital photos based on some theme and upload them to the Animoto web site. You then select a sound track (classical, jazz, rap, electronica, etc.) to go with the photos. And last, you tell Animoto to create a video combining the photos and music. The process is fun and the results can be awesome.

When finished, you can email a link to the video to anyone. You can also post the video to web sites like this blog. That's exactly what I did with this sample video created from photos taken on a recent trip to Munich.

I'd venture to guess that there are also some commercial uses for this service. For example, if you are a vendor who will be going to a trade show, you could create a pretty compelling video to replace those ugly PowerPoint presentations you may already have.

Give it a try.

Thursday, 27 March 2008 in 90 Diversions | Permalink | Comments (0) | TrackBack (0)

Technorati Tags: Animoto, Laszlo Letter, photo animation, slide animation, video production

Downgrading from Vista to XP

If you recently bought a new PC or laptop, it is likely that it came packaged with the MS Vista operating system. Unfortunately, while Vista may be prettier than XP, it comes with a lot of baggage and some erratic/annoying behavior. Personally, I hate it.

Assuming that you work for a biopharma company, it is also likely that they have not yet switched to Vista and will not support any machine that is running it. So, if you want to do something work related on your Vista machine, you won't be able to get technical support from your employer.

If you are just now in the market for a new PC/laptop, then make sure that it comes pre-loaded with XP and not Vista. You will specifically have to ask for this "downgrade."

If you are in the less enviable position of having a PC with Vista already on it, then you will need to take the somewhat painful step of converting from one OS to another. Luckily, there is a new article in Information Week that will help you prepare for and execute this task. Make sure you set aside a whole morning or afternoon for this, since I don't believe the statement in the article that it should only take a few hours!

Tuesday, 22 January 2008 in 90 Diversions | Permalink | Comments (1) | TrackBack (0)

Technorati Tags: Laszlo Letter, Microsoft, operating system, Vista, XP

USA Presidential Candidate Healthcare Proposals

A Public Service Announcement

Healthcare is a top-of-mind issue for most of us living in the United States. Perhaps it is a lesser issue for those in the 18-29 age group, the segment of the population that is most looking forward to a drastic change in direction for the country. Anyone older, however, is truly concerned about adequate or catastrophic healthcare coverage.

So, how is one to tell how well each of the Presidential candidates have thought about this issue? Luckily, Stephen Beller has taken the time to do such a comparison and it's my intent here to just let you link to it and decide for yourself which candidate offers the "best" solution.

Happy reading!

Tuesday, 08 January 2008 in 90 Diversions | Permalink | Comments (0) | TrackBack (0)

Technorati Tags: Healthcare, Insurance, Laszlo Letter, Presidential Elections, Stephen Beller, United States

The Reading List - 1Q 2008

In the era of instant gratification, it is good to remember that it sometimes pays to take a deeper dive into certain subjects. With that in mind, here is a list of books that will be published in the first quarter of 2008.

If you like controversy, February and March are the months for you when the following titles will hit the streets:

  • Before You Take that Pill: Why Big Pharma Is Bad for Your Health.
  • Values in Medicine: What are We Really Doing to Patients?
  • Our Daily Meds: How the Pharmaceutical Companies Transformed Themselves into Slick Marketing Machines and Hooked the Nation on Prescription Drugs

So, put down that magazine and curl up with a good book.

Continue reading "The Reading List - 1Q 2008" »

Thursday, 03 January 2008 in 90 Diversions | Permalink | Comments (0) | TrackBack (0)

Technorati Tags: Biotechnology, Books, Laszlo Letter, Pharmaceutical Industry, Reference books

Will the Internet kill books?

Well NO.

It is more likely that over time we will see electronic publishing becoming the norm with "on demand" printing of entire books moving from the print shop to the book store or your personal computer.

We actually have a pretty good analogy to this in our own industry. That is, the move to electronic submission publishing including electronic delivery and the potential to go to print on an "as needed" basis.

Technology will need to come to the rescue once again and allow these "one off" books to be printed and bound quickly and at a quality equal to what is currently expected by consumers. Some "on demand" printers are already available and can print a single page in a split second in full color. So, you can expect to see them show up at your favorite large book chain fairly soon. I'd say in the next two years. Remember though that I tend to be an optimist and may be off by a year or two.

This leads to an interesting question. Just how many books are we talking about?

According to R.R. Bowker, there were close to 300,000 books published in 2006 in the United States alone. For the entire English-speaking world, the number increases to over 450,000.

The top publishing categories for 2006 in the USA were as follows:

  • Fiction 42,000
  • Juvenile 29,000
  • Sociology/Economics 25,000
  • Religion 18,000
  • History 14,000
  • Science 13,000
  • Philosophy/Psychology 13,000
  • Medicine 11,000
  • Biography 10,000
  • Poetry/Drama 10,000
  • Arts 9,000
  • Business 9,000
  • Literature 8,000
  • Technology 7,000
  • Education 7,000
  • Sports/Recreation 6,000
  • Computers 5,000

And I have no idea how many times Paris Hilton is mentioned in any of these books. However, it would be interesting to see the breakout by category.

Note: I have rounded the figures up or down to the nearest 1,000. For example, the actual count for computers is 5,498.

'

Saturday, 08 December 2007 in 90 Diversions | Permalink | Comments (0) | TrackBack (0)

Technorati Tags: books, Bowker, ebooks, Laszlo Letter, on-demand printing, publishing

The Real Thanksgiving

First, let me wish you a wonderful Thanksgiving.

This one is my favorite holiday. It's really the only one where the empasis is on friends and family and does not bring with it a host of obligations. You can simply get together with those you love and have a good time.

So, we owe a thanks to the Pilgrims who landed at Plymouth back in the 1600's and the Wampanoag native american indian tribe that helped them survive and celebrate their first thanksgiving in Massachusets.

So, if you care to know about how all this happened and its aftermath, read on. Then, if you are really interested, follow this link to find out what separates myth from reality about the Thanksgiving story.

Continue reading "The Real Thanksgiving" »

Thursday, 22 November 2007 in 90 Diversions | Permalink | Comments (2) | TrackBack (0)

Havidol: Just don't take this too seriously

Havidol The October issue of Pharmaceutical Executive came with a supplement entitled "Guide to Branding." Unlike most people, I tend to look at these supplements before relegating them to the trash bin. And so, it was with distinct pleasure that the article on Page 8 led me to the following web site:

                                                          Havidol

Check out the site. Then read the article.

Just don't try to get an Rx for this stuff from your physician!

Tuesday, 13 November 2007 in 45 Sales & Marketing, 90 Diversions | Permalink | Comments (0) | TrackBack (0)

Technorati Tags: advertising, brand management, branding, Havidol, Justine Cooper, Laszlo Letter

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